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May 7, 2009

Paladin and Isotechnika Combine Forces to Advance Latter's Immunosuppressant

Paladin and Isotechnika Combine Forces to Advance Latter's Immunosuppressant

  • Paladin Labs and Isotechnika entered a strategic alliance to advance development and commercialization of Isotechnika’s voclosporin. The drug, a next-generation calcineurin inhibitor, recently completed a Phase III trial in psoriasis and a Phase IIb study in the prevention of kidney rejection following transplantation.

    Under their agreement, the companies have formed a new firm, which will be called Isotechnika Pharma and will take care of development activities. Isotechnika will provide $4.35 million in R&D funding, and Paladin will own 19% of the new entity.

    According to the commercialization terms of deal, Paladin paid Isotechnika $7 million for rights in Canada, Mexico, Central and South America, Israel, and South Africa.  Isotechnika Pharma will be entitled to royalties on Paladin's sales in these territories, and Paladin will receive royalties on the sales of voclosporin in other markets.

    Over the longer term, Paladin expects that its commercialization expertise and Isotechnika's background in drug discovery and development will identify and acquire through Isotechnika Pharma additional late-stage clinical assets.

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MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

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