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Jun 11, 2010

Otonomy Secures $10M to Advance Therapeutics for Hearing and Balance Disorders

  • Otonomy completed a $10 million Series A financing with Avalon Ventures. The funding will be used to support ongoing clinical investigations of OTO-104 in Meniere disease, initiate IND-enabling studies for OTO-203, and continue early-stage development of a third program.

    OTO-104 is a sustained-release formulation of the steroid dexamethasone. Otonomy is conducting a prospective, randomized, placebo-controlled, multicenter Phase Ib study with OTO-104 given as a single intratympanic (IT) injection in subjects with unilateral Meniere disease. Preclinical studies have demonstrated that the compound can effectively deliver a prolonged and dose-proportional exposure of dexamethasone to the inner ear and is well-tolerated in a broad set of safety evaluations, according to the company.

    The firm is also planning studies with OTO-104 for acute hearing loss. OTO-203 is a sustained-release antibiotic being developed for the treatment of otitis media. Otonomy’s pipeline is focused on therapies for disorders of the inner and middle ear.


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