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Apr 11, 2007

Novosom to Option CD40-Targeted Antisense Inhibitors from Isis

  • Novosom purchased an exclusive option from Isis Pharmaceuticals related to antisense inhibitors targeting the CD40 membrane protein for all indications. If exercised within six months, Novosom will acquire an exclusive, worldwide license.

    CD40 is a validated target for both inflammatory diseases and B-cell cancers. Novosom plans to target CD40 for indications such as Crohn's disease, transplant, rheumatoid arthritis, cancer, and multiple sclerosis. If acquired, the license from Isis would include rights to the target and to oligonucleotides targeting CD40 and incorporating Isis' second-generation antisense chemistry, 2' MOE oligonucleotides. 

    Novosom is using its Smarticles® technology to enable systemic delivery of antisense targeting CD40. This encapsulated antisense approach has demonstrated targeted delivery to specific cell types with a rapid onset of action, according to the company.



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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

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