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Sep 27, 2006

Novartis Scientists Discovered Activators of PGC-1a Transcription

  • Novartis published their use of OriGene’s full-length cDNA collection to identify novel activators of PGC-1a transcription. This work was recently published in the journal Proceedings of the National Academy of Sciences titled “Transducer of regulated CREB-binding proteins (TORCs) induces PGC-1a transcription and mitochondrial biogenesis in muscle cells.”

    PGC-1a is a co-activator of PPAR-g and regulator of adaptive thermogenesis. Activators like TORCs can serve as potential therapeutic targets to modulate mitochondrial function.



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Cancer vs. Zika: What Worries You Most?

While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country’s most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?

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