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Sep 27, 2006

Novartis Scientists Discovered Activators of PGC-1a Transcription

  • Novartis published their use of OriGene’s full-length cDNA collection to identify novel activators of PGC-1a transcription. This work was recently published in the journal Proceedings of the National Academy of Sciences titled “Transducer of regulated CREB-binding proteins (TORCs) induces PGC-1a transcription and mitochondrial biogenesis in muscle cells.”

    PGC-1a is a co-activator of PPAR-g and regulator of adaptive thermogenesis. Activators like TORCs can serve as potential therapeutic targets to modulate mitochondrial function.



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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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