Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Feb 21, 2012

Novartis Pays Enanta $34M Up Front for Worldwide Rights to HCV NS5A Inhibitors

  • Novartis is paying Enanta Pharmaceuticals $34 million up front for worldwide rights to develop and commercialize the latter’s lead HCV NS5A inhibitor candidate, EDP-239. Enanta could receive up to $406 million in clinical, regulatory, and commercial milestones plus tiered double-digit royalties on sales and retains co-detail rights in the U.S.

    Under terms of the deal Novartis will shoulder all costs associated with the development, manufacture, and commercialization of EDP-239. It will also provide Enanta with funding for the discovery of additional compounds targeting NS5A.

    NS5A is a nonstructural viral protein that is critical for viral replication. Enanta says its EDP-239 inhibitor has demonstrated high potency against multiple HCV genotypes in vitro, and its preclinical pharmacokinetic profile supports the potential for once-daily dosing in humans.

    Anti-infectives specialist Enanta is developing HCV protease, polymerase, and cyclophilin-based inhibitors and has generated a class of macrolide antibiotics, called bicyclolides, which it claims can overcome bacterial resistance. The firm teamed up with Abbott in 2006 to develop and commercialize HCV HS3 and NS3/4A protease inhibitors through a $57 million cash and equity investment deal that also gives its partner access to drug discovery capabilities in the field of HCV NS3 and NS3/4A protease inhibitor field. Enanta’s HCV polymerase and cyclophilin programs are ongoing in house.

    Enanta’s bicyclolide program is focused on the development of oral broad-spectrum candidates against community MRSA and community-acquired respiratory tract infections caused by pathogens including S. pneumonia, S. aureus, S. pyogenes, and H. influenza as well as a hospital-acquired MRSA and VRE.

Related content


GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

What Does Brexit Mean for Biotech?

Do you agree with the contention that Brexit will NOT have a long-term negative impact on the British biotech industry?

More »