Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Jul 15, 2009

Novartis and OneWorld Health Join Forces against Secretory Diarrhea

  • Novartis and the Institute for OneWorld Health signed a three-year collaboration to develop a treatment for secretory diarrhea that targets the cystic fibrosis transmembrane conductance regulatory (CFTR) chloride ion channel. Novartis will carry out all research and assume associated costs, with OneWorld Health having responsibility for subsequent preclinical and clinical development.

    OneWorld Health has been working on an antisecretory diarrhea therapy since 2006, funded by a $47 million grant from the Bill and Melinda Gates Foundation. The work was based on research carried out at the University of California, San Francisco. The new collaboration will now take advantage f Novartis’ knowledge in the area of CFTR structure and function.

    In cystic fibrosis, the CFTR gene mutation leads to a buildup of mucus in the lungs, but in secretory diarrhea the infectious agents or toxins induce CFTR hyperactivity that results in excessive loss of water from the body via the gastrointestinal tract. OneWorld believes that because infectious diarrhea is often caused by over-activation of the CF channel, an inhibitor could represent an effective addition to currently available treatments, which are based on oral rehydration, by helping to reduce fluid and electrolyte loss.


Related content


GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

What Does Brexit Mean for Biotech?

Do you agree with the contention that Brexit will NOT have a long-term negative impact on the British biotech industry?

More »