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Sep 3, 2008

Neurologix Licenses to Aegera’ XIAP Gene for Use in Huntington’s

  • Neurologix gained rights to Aegera Therapeutics’ x-linked inhibitor of apoptosis protein (XIAP) gene for therapeutic and prophylactic purposes in the treatment of Huntington’s disease. The exclusive agreement gives Neurologix worldwide rights excluding China. XIAP is an inhibitor of caspases, a family of proteins that are executors of apoptosis.

    “We have been very encouraged by our preclinical results to date, which demonstrate that XIAP may not only modify the progression of cell death but may potentially reverse neuronal dysfunction as well,” John Mordock, president and CEO of Neurologix says.

    In preclinical studies, Neurologix scientists showed that a mutated form of the XIAP delivered by an adeno-associated virus vector slows the disease and normalizes motor deficits associated with the disease when introduced into the brain of mice harboring the same mutation found in humans.



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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

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