GEN Exclusives

More »

GEN News Highlights

More »
Jan 20, 2010

MorphoSys Expands Deal Leveraging Wacker’s Bacterial Secretion Technology

  • MorphoSys and Wacker Chemie expanded their existing collaboration to use Wacker's bacterial secretion technology, Esetec®. MorphoSys will now be able to leverage Esetec for the production of antigen material in addition to the production of antibodies in both the early development phase of therapeutic projects as well as in the production of diagnostic and research antibodies.  

    The Esetec secretion system produces proteins including antibody fragments. The system comprises a specific E. coli strain developed by Wacker that is able to secrete recombinant proteins in their native conformation into the culture medium during fermentation, according to the company. This extracellular production facilitates the purification of recombinant products, and the step of refolding is eliminated. 

    Wacker and MorphoSys first entered into a feasibility study agreement for the use of Esetec for antibody production in 2005. Due to the success of the collaboration, this agreement was supplemented in 2008 with a formal license to use the Wacker technology.


Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

The Triple Package and Success

One theory for explaining “success," put forward by Amy Chua Jed Rubenfeld, posits cultural traits such as a superiority complex, personal insecurity and impulse control. Union College professors Joshua Hart and Christopher Chabris counter that intelligence, conscientiousness, and economic advantage are the most likely elements of success, regardless of ethnicity. Do you think that Hart-Chabris make a better argument for achieving success than the Chua-Rubenfeld theory?

More »