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May 24, 2007

Micromet Could Earn $167M in Alliance with Nycomed

  • Micromet and Nycomed will collaborate on the development of anti-GM-CSF antibodies that may be useful for the treatment of inflammatory and autoimmune diseases. The lead product candidate is Micromet's MT203, a human antibody that neutralizes granulocyte macrophage colony-stimulating factor (GM-CSF).

    Preclinical studies support the development and evaluation of MT203 for the treatment of rheumatoid arthritis, multiple sclerosis, psoriasis, asthma, and chronic obstructive pulmonary disease, according to Micromet. The candidate is expected to enter clinical trials in 2008.

    Under the terms of the agreement, Micromet will receive an upfront license fee of approximately $7 million, or EUR 5 million. It also is eligible to receive R&D reimbursements and payments upon the achievement of development milestones of more than $160 million, EUR 120 million. In addition, the company will earn royalties on worldwide sales of MT203 and other products that may be developed under the agreement.

    Micromet will be primarily responsible for performing preclinical development, process development, and manufacturing for early clinical trials. Nycomed will handle clinical development and commercialization on a worldwide basis. Nycomed will bear the cost of development activities and reimburse Micromet.



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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

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