GEN Exclusives

More »

GEN News Highlights

More »
Jul 5, 2012

MDxHealth, Merck KGaA Partner to Develop Companion Dx for Glioblastoma Drug

  • MDxHealth and Merck KGaA expanded their diagnostics collaboration to encompass further development and commercialization of MDxHealth’s MGMT (methylguanine-DNA methyltransferase) diagnostic test PredictMDx™ for glioblastoma as a test to identify patients who may benefit from treatment using Merck Serono’s Phase III-stage integrin inhibitor cilengitide.

    Under terms of the deal Merck will support MDxHealth’s development and regulatory activities for the MGMT test and, after regulatory approval, coordinate launch of the test alongside cilengitide for glioblastoma therapy. The PredictMDx for glioblastoma test assesses the methylation status of the MGMT gene promotor as an indicator of whether tumor cells will respond to some types of chemotherapy agents.

    The assay has already been applied to identify and stratify newly diagnosed glioblastoma patients enrolled in clinical studies evaluating cilengitide in combination with temozolomide and radiotherapy. MDxHealth has additional agreements in place for use of the PredictMDx for glioblastoma assay to help select patients for Phase III studies evaluating other investigational drugs in combination with temozolomide and radiotherapy. 


Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content

Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

Should the CDC Director Resign?

Do you think the CDC chief should resign?