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Feb 9, 2009

Ligand Earns $1M Milestone from Schering-Plough

  • Ligand Pharmaceuticals earned a $1 million milestone payment from Schering-Plough related to the progress of Schering-Plough’s inhibitor of b-site of APP cleaving enzyme (BACE) for the treatment of Alzheimer's disease.

    The milestone payment arises from a drug discovery agreement between Schering-Plough and Pharmacopeia (acquired by Ligand), wherein Pharmacopeia contributed to Schering-Plough’s medicinal chemistry optimization programs.

    Under the terms of the collaboration agreement, Ligand is eligible to receive additional payments from Schering-Plough upon the achievement of certain development and regulatory milestones. Ligand is also eligible to receive royalties on potential sales of the drug. In addition to the BACE program, the collaboration with Schering-Plough has resulted in several Phase I and II programs in multiple therapeutic areas.



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MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

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