GEN Exclusives

More »

GEN News Highlights

More »
Jun 6, 2012

Janssen’s Stelara Improves Active Psoriatic Arthritis in Phase III Study

  • Janssen reported positive data from a Phase III trial evaluating the interleukin 12 and interleukin 23 inhibitor Stelara® (ustekinumab) in patients with active psoriatic arthritis. The drug is currently only approved for treating plaque psoriasis in patients who are suitable for phototherapy or systemic therapy.

    The placebo-controlled Psummit I study included 615 patients who had active psoriatic arthritis despite treatment with disease-modifying antirheumatic drugs and/or nonsteroidal anti-inflammatory drugs. The results showed that 42% of participants receiving 45 mg of Stelara, and 50% of patients treated using the 90 mg dose, achieved at least a 20% improvement in ACR criteria (ACR20) at week 24, compared with just 23% of placebo-treated patients. Stelara was dosed at weeks 0, 4, and then every 12 weeks. A significantly higher proportion of Stelara-treated patients also achieved ACR50 and ACR70 than those receiving placebo. The treatment in addition led to clinically relevant improvements in physical function, including enthesitis and dactylitis.

    The Psummit 1 data also confirmed that treatment with Stelara was associated with significant improvements in EULAR/Disease Activity Score (DAS) 28 C-reactive protein responses. At week 24, 66% and 68% of patients receiving 45 mg and 90 mg of Stelara, respectively, reported EULAR/DAS-CRP response, compared with 34% of placebo patients. The drug was associated with marked improvements in plaque psoriasis, with up to 62% of patients on the high dose achieving at least a 75% improvement, compared with just 11% of placebo-treated patients.

     


Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content

Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

Alzheimer's Therapies

Do you think an effective treatment for Alzheimer’s will be found within the next 10–15 years?