Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Oct 3, 2007

Isis Obtains $1.5M to Improve Properties of RNAi-Based Drugs

  • Isis Pharmaceuticals received a phase 2 SBIR grant from the NIH for up to $1.5 million to design oligonucleotide therapeutics that exploit the RNAi antisense mechanism.

    The phase 2 funding builds upon a successful phase 1 program that demonstrated the feasibility of using single-stranded antisense drugs to target the RNAi pathway.

    “Based on our extensive work with single-stranded antisense drugs that work through an RNase H mechanism and the feasibility studies we have completed with single-stranded antisense drugs that harness the RNAi pathway, we are optimistic that the two drug families will share certain characteristics including bioavailability and tissue distribution,” points out C. Frank Bennett, Ph.D., svp of research.

    The multiyear NIH backing will fund research to improve the stability and tissue distribution of RNAi drugs. Isis says that much of the work will focus on optimizing the chemical properties of single-stranded oligonucleotides that trigger the RNAi pathway.


GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

Pharmacists and Prescription Drug Misuse Programs

Do you agree that pharmacists should make a greater effort to become more involved with prescription drug-monitoring programs?

More »