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Jun 24, 2009

ImmunoCellular Contracts Formatech to Produce Cancer Vaccine for Phase I Study

  • Formatech will manufacture ImmunoCellular Therapeutics’ (IMUC) cancer stem cell (CSC) vaccine candidate, ICT-121, for an upcoming clinical trial. The Phase I study will target glioblastoma and is expected to begin early next year, pending clearance by the FDA.

    “ICT-121 has shown its ability in preclinical studies to target and destroy cancer stem cells present in brain tumors, so we are excited to initiate this trial in the coming months,” says Manish Singh, Ph.D., president and CEO of IMUC. ICT-121 may have applicability to other cancer types, the company adds.

    ICT-121 consists of a peptide that stimulates a cytotoxic T-lymphocyte response to CD133, which is generally overexpressed on the CSCs. While glioblastoma will be the initial target for ICT-121, CD133 is also overexpressed in colon, breast, liver and prostate cancers as well as multiple myeloma and melanoma.

    Related News

    Opinion: A Stem of Hope for Cancer Treatments (June 12, 2009)
    Special Report: Customized Cancer Vaccines Finally (Maybe) Arrive (June 12, 2009)
    Biovest’s Stock Value Triples with Phase III Data on Lymphoma Vaccine (June 1, 2009)
    Gamida Obtains Rights to Amgen Cytokines to Produce Stem Cell Cancer Drug (July 21, 2008)
    Adjuvant IL-7 Boosts Vaccine-Induced Immune Response to Tumors (Apr. 27, 2009)
    ImmunoCellular Augments Anticancer Vaccine Business with mAb Technology from Molecular Discoveries (Nov. 27, 2007)

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MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

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