GEN Exclusives

More »

GEN News Highlights

More »
Sep 15, 2011

Horizon Raises $18.6M in Series C Financing to Broaden Utility of X-Man Platform

  • Horizon Discovery completed a second closing of a Series C financing round, which has raised a total of $18.6 million. The firm says it aims to use the funds to improve its technology platforms and expand into new disease areas outside of its traditional focus on cancer.

    U.K.-based Horizon’s core rAAV-based gene-engineering platform, Genesis, is being exploited to develop its expanding X-Man™ (mutant and normal) portfolio of genetically defined and patient-relevant cell lines for modeling disease-causing mutations in cancer.

    The panel currently includes over 350 X-Man lines that have been either developed in house or licensed in. Within the last few months alone the firm has acquired licenses to isogenic cell lines relevant to viral infections (from the University of Minnesota), DNA repair (from Public University Corporation Yokohama City University), and for studies on miRNA21 (from the University of Pittsburgh), which is implicated in a range of cancers.

    In April Horizon established a three-year collaboration with the Fox Chase Cancer Center focused on the discovery of genes involved in resistance to EGFR-targeted therapies, through which the partners will establish a Center of Excellence in Mammalian Gene Editing. In March the firm received a $1.6 million grant from the EU’s Seventh Framework Program (FP7) to participate in the Coltheres (Colon Cancer and Therapeutics) Consortium, through which it will develop X-Man cell lines that incorporate predictive biomarkers of drug response identified through the Coltheres initiative. At the start of 2011, Horizon announced a two-year research collaboration with the University of Washington focused on generating a process for gene editing in inducible human pluripotent stem cells.

Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

Patient Access to Genetic Information

Do you think patients have the absolute right to gain access to their own genetic information from medical or clinical laboratories?

More »