Horizon Discovery obtained exclusive, worldwide licenses to human gene-targeting technologies developed by scientists at the University of Washington. The technologies involve the use of parvoviral vectors in human genome engineering.
Horizon aims to combine the licensed capabilities with its own Genesis platform to generate a range of genetically stable and optimized, high-yielding human cell lines for producing biopharmaceuticals. The company says that the ability to engineer human adult stem cells or reprogram stem cells derived from differentiated somatic human cell lines will allow it to generate an expanded and diversified portfolio of its X-Man human isogenic cell lines for predicting the response to drugs targeting cancer-related genes.
The technology’s inventor, David Russell, M.D., Ph.D., has been appointed a special member of Horizon’s scientific advisory board. Darrin M Disley, Ph.D., Horizon’s chairman, notes that the company’s relationship with the University of Washington has already been fundamental to the development of Horizon.
“The ability to precisely and stably alter the genome of mammalian and especially human cell lines without introducing errors or exogenous vector sequences opens up several opportunities for our products and services in Rx and Dx development as well as bioproduction markets.”