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Dec 10, 2007

GSK Puts Down $6M for Phase I Trial Initiation of Targacept’s Pain Candidate

  • Targacept initiated a Phase I trial of TC-6499, triggering a $6 million milestone payment from GlaxoSmithKline (GSK). This early-stage small molecule is being  initially developed as a treatment for neuropathic pain.

    In July, GSK and Targacept entered a partnership worth over $1.5 billion for novel therapeutics that selectively target specified neuronal nicotinic receptors (NNRs). The advancement of TC-6499 marks the first reported milestone. Targacept is eligible to receive an additional milestone fee if the company determines to advance TC-6499 into Phase II.

    TC-6499 was discovered using Targacept’s drug design technology known as Pentad™. “TC-6499 represents the third Pentad-enabled product candidate that we have advanced into the clinic this year, demonstrating the strength of Pentad, our ability to execute our operating plans successfully, and the breadth and pharmacological diversity of our pipeline of NNR Therapeutics,” comments J. Donald deBethizy, Ph.D., Targacept’s president and CEO.



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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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