Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Sep 17, 2012

Funding for Stem Cell Treatment of Compartment Syndrome

  • America Stem Cell (ASC) won an Advanced Technology Small Business Technology Transfer Research (STTR) grant from the National Heart Lung and Blood Institute (NHLBI) to evaluate the use of its ASC-101 stem technology in combination with the Wake Forest Institute of Regenerative Medicine’s (WFIRM) amniotic fluid-derived stem cells in an experimental model of compartment syndrome. The condition can arise following a range of injuries including fractures, burns, trauma, post-ischemic swelling, and gunshot wounds, leading to loss of muscle tissue.

    ASC-101 is a human recombinant enzyme technology designed to increase the efficiency of engraftment of cord blood-derived stem cell transplants, and enhance the ability of other types of stem cell to home in on their target tissues. A number of collaborations are in place to evaluate the potential to use ASC-101 for improving cell therapies for multiple conditions using a range of cell types. Initial clinical trials with ASC-101 are ongoing in hematopoietic stem cell transplantation.

    The firm says the STTR grant will allow it to evaluate combining its technology with amniotic fluid-derived stem cells. “The combination of ASC-101 with amniotic fluid-derived stem cells could synergistically enhance the therapeutic and regenerative capacity of these cells and most importantly provide an off-the-shelf, effective solution for tissue damage due to multiple types of injuries or diseases,” remarks Lynnet Koh, ASC’s CEO.“

Related content

Be sure to take the GEN Poll

Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

More »