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Nov 1, 2012

Firms Combine Technologies to Optimize ChIP Studies

  • Rubicon Genomics and Diagenode agreed to integrate the former’s ThruPLEX® sample preparation technology into Diagenode’s epigentics platforms to improve DNA sample preparation for chromatin immunoprecipitation (ChIP) applications, in particular its new MicroPlex Library Preparation Kit for ChIP-seq studies.

    Diagenode develops instruments and reagent systems for life science applications, with a focus on epigenetics research and molecular diagnostics. The firm offers a range of kits for chromatin immunoprecipitation, and the SX-8G IP-Star® Compact Automated System for ChIP and DNA methylation analysis.

    Preanalytical sample preparation specialist Rubicon’s ThruPLEX-FD platform is a next-generation sequencing prep technology for the synthesis and amplification of ChIP DNA that uses a one-tube, three-step process. The firm says the technology can generate high-quality DNA from small samples, requires no intermediate purification steps, transfers, columns or gels, and can be used in plasma, FFPE, cDNA. Kits are available for sequencing on Illumina®, HiSeq®, MiSeq, and Genome Analyzer instrumentation. Development is ongoing for additional formats and platforms.

    “We are pleased to add the Rubicon ThruPLEX technology to Diagenode’s high-quality product line for ChIP studies,” comments Didier Allaer, Diagenode’s founder and CEO. “It’s fast, easy-to-use, and sensitive, producing high-quality results from challenging samples. We will also offer the MicroPLEX and True MicroChIP kits to our customers in conjunction with our new SX-8G IP-Star automated system, the first comprehensive system to automate ChIP and DNA methylation analysis.”



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