Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Apr 23, 2007

Faulty Gene Repair Leads to Huntington’s Disease

  • Researchers discovered that a miscue of the body’s genetic repair system may cause Huntington’s disease. "We showed that when single-strand breaks in DNA caused by oxidative lesions were repaired, the Huntington’s gene continued to add extra replacement segments," explains Cynthia McMurray, Ph.D., a Mayo Clinic molecular biologist who led the study. "Over time, this expansion—especially in nerve cells—becomes toxic."

    In their study of transgenic mice that carried the human Huntington’s gene, the researchers noted that the repeated tracts of replacement repair segments seem stable until the animals reach about four months. After that point, which represents middle age for a mouse, the segments expand and continue to do so as the animals age.

    Researchers also showed that the expansion of the tracts, an inherited characteristic, caused toxicity in cells that cannot expand, such as nerve cells. The result is that cell death acceleration is directly proportional to the additional repeated lengths.

    In a further step, the team eliminated a key enzyme, OGG1, related to DNA repair for oxidative lesions and found that it stopped or greatly reduced segment growth.

    The findings appear in the online issue of Nature.



Be sure to take the GEN Poll

Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

More »