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Jan 10, 2007

Erbitux Phase III Metastatic Colorectal Cancer Study Meets Primary Endpoint

  • ImClone Systems and Bristol-Myers Squibb reported that a Phase III study of Erbitux in metastatic colorectal cancer (mCRC) showed positive results. Erbitux (cetuximab) plus Folfiri (an irinotecan-based chemotherapy) increased median duration of progression-free survival over Folfiri alone in patients with previously untreated mCRC.

    "These results provide important new information for patients with metastatic colorectal cancer and are part of a comprehensive clinical development program designed to fully understand the potential uses of Erbitux for cancer patients," says Martin Birkhofer, M.D., vp, oncology global medical affairs, Bristol-Myers Squibb.

    The study, in which more than 1,000 patients participated, was conducted by Merck KGaA, ImClone’s Erbitux partner outside of North America. The company hopes to present the results at the ASCO Annual Meeting in June.

    Erbitux’ current indications are related to squamous cell carcinoma of the head and neck and EGFR-expressing metastatic colorectal carcinoma.

     



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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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