Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Mar 10, 2011

Epizyme and Eisai Form Strategic Partnership Targeting EZH2 for Treatment of Lymphoma

  • Epizyme and Eisai have formed a worldwide strategic partnership to discover, develop, and commercialize therapeutics targeting the epigenetic enzyme EZH2 for the treatment of lymphoma and other cancers in genetically defined patients.

    EZH2 is among small molecule histone methyltransferase inhibitors whose discovery and development Epizyme focuses on.

    Epizyme will receive $6 million in up-front and initial milestone payments, and may earn more than $200 million in additional research, development, and sales milestones, and up to double-digit royalties. Additionally, Eisai will fund 100% of R&D through human proof-of-concept, at which point Epizyme has the right to opt into a profit share and co-commercialization arrangement for the United States.

    “The U.S. profit share and co-commercialization option is a key element of our strategy to discover, develop, and also to commercialize epigenetic medicines,” states Robert Gould, Ph.D., president and CEO of Epizyme.

     

     

     

     



Related content

Be sure to take the GEN Poll

Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

More »