GEN Exclusives

More »

GEN News Highlights

More »
Feb 9, 2012

Endece, MRF to Progress Myelin Regeneration Candidates into Clinic

  • The Myelin Repair Foundation (MRF) and Endece Neural established a partnership to progress the latter’s myelin regeneration drug candidates through preclinical development and into Phase I studies for the treatment of multiple sclerosis (MS). Endece Neural is the neurological drug development subsidiary of Wisconsin-based Endece. As part of the collaboration, the MRF’s newly established Translational Medicine Center will evaluate the myelin regenerating capabilities of Endece’s small molecule candidates using MS models.

    “We approached the Myelin Repair Foundation about joining forces because of their expertise in myelin repair models, in addition to their new in-house capabilities at the MRF Translational Medicine Center,” explains James Yarger, Ph.D., Endece Neural’s president. “Unlike current MS therapies, which target immune response and inflammation to slow relapses, our drug compounds are promising candidates for remyelination, with the potential to restore muscle control and mobility.”

    Endece is focused on the discovery and development of small molecule drugs that target receptors controlling metabolic pathways. The firm’s lead preclinical programs are focused on oncology and, through Endece Neural, multiple sclerosis. The latter’s NDC-1022 candidate is a small molecule that modulates estrogen receptor activity primarily by binding and activating ER-β. Endece says the drug is being developed as a treatment for neurodegenerative diseases such as MS, as it leads to significant up-regulation of proteins involved in the process of nerve axon remyelination.

Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

Easing Restrictions for Terminal Patients

Should the Federal Government Pass a “Right to Try” Bill Allowing Terminally Ill Patients Access to Experimental Medicines?

More »