GEN Exclusives

More »

GEN News Highlights

More »
Apr 30, 2010

Critical Biologics to Use Scarab’s Clean Genome E. coli for Production of Phase II Gelsolin Replacement Therapy

  • Critical Biologics negotiated a license to Scarab Genomics’ Clean Genome® E. coli platform for the production of its Phase II-stage recombinant human plasma gelsolin (rhu-pGSN), Solinex. The deal also allows Scarab to use rhu-pGSN as a test protein for demonstrating its bacterial production technology to prospective clients.

    Critical Genomics says the Clean Genome E. coli technology appears to significantly maximize production efficiency and optimize cloning performance. “We have been deeply impressed by Scarab’s fivefold increase in production yield to over 13 g/L at 5 L batch scale,” remarked Ashleigh Palmer, Critical Genomics’ CEO.

    Scarab Genomics’ Clean Genome E. coli is an engineered K12 strain in which over 15% of the genome has been deleted, including transposable insertion sequences and prophage. The firm claims this genome reduction optimizes E. coli as a biological factory, with elimination of nonessential genes as well as recombinogenic or mobile DNA, toxins, and virulence genes provides increased genome and plasmid stability and improved metabolic efficiency.

Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

The Triple Package and Success

One theory for explaining “success," put forward by Amy Chua Jed Rubenfeld, posits cultural traits such as a superiority complex, personal insecurity and impulse control. Union College professors Joshua Hart and Christopher Chabris counter that intelligence, conscientiousness, and economic advantage are the most likely elements of success, regardless of ethnicity. Do you think that Hart-Chabris make a better argument for achieving success than the Chua-Rubenfeld theory?

More »