GEN Exclusives

More »

GEN News Highlights

More »
Apr 21, 2008

Charlesson Awarded Almost $1.6M from NIH to Advance AMD Mouse Model and Ocular Disease Drug Candidate

  • Charlesson received two SBIR grants from the NIH totaling close to $1.6 million to support development of a nanoparticle-formulated therapy for eye disease and a preclinical genetic animal model for age-related macular degeneration (AMD).

    Specifically, the firm obtained $210,357 to validate and commercialize its mouse model of AMD. Charlesson also received  over $1.38 million in a phase 2 SBIR grant to develop CLT-004 for treating AMD, diabetic retinopathy, and diabetic macular edema. These funds will be used to develop IND-enabling efficacy, safety, and toxicity profiles.

    CLT-004 is a small molecule that reduces retinal inflammation and vascular leakage, according to Charlesson. The firm is developing a sustained-release nanoparticle formulation of CLT-004 to treat blinding retinal disease.



Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

Stopping Research Fraud

What is the best approach to curbing scientific misconduct and outright fraud?