Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Jan 4, 2010

Cancer Research UK to Conduct Phase I Trial with Merck KGaA’s B-Cell Lymphoma Candidate

  • Cancer Research UK and Cancer Research Technology, the charity’s development and commercialization arm, are taking over preclinical and early clinical development of Merck KGaA’s leukemia and lymphoma candidate called DI-B4.

    Cancer Research UK will fund a Phase I trial with DI-B4, a CD19-targeting mAb. Merck retains the option to take the antibody through later-stage clinical development and commercialization in return for future payments to the charity. If the company decides not to exercise this option, Cancer Research Technology will be given rights to the antibody to look for other partnership opportunities.

    DI-B4 will be one of the first drugs manufactured at Cancer Research UK’s new £20 million (about $32.33 million) Biotherapeutic Development Unit. It was designed for the development and GMP manufacture of biotherapeutics including viruses for clinical trials. The Phase I trial with Dl-B4 will involve about 20 to 40 patients with advanced B-cell lymphoma.

    The deal comes under Cancer Research UK’s Clinical Development Partnership program. The center says that DI-B4 is the fourth anticancer drug to enter this program, which was established in 2006.


Related content

Be sure to take the GEN Poll

Cancer vs. Zika: What Worries You Most?

While Zika continues to garner a lot of news coverage, a Mayo Clinic survey reveals that Americans believe the country’s most significant healthcare challenge is cancer. Compared to other diseases, does the possibility of developing cancer worry you the most?

More »