Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Oct 6, 2008

Biolex to Take Over Full Rights to Investigational Hep C. Drug from Octoplus for $11M

  • Biolex Therapeutics is paying OctoPlus $11 million for its 50% share of commercial rights to Locteron for hepatitis C. Biolex also agreed to pay up to $138 million in development and sales milestones. Additionally, OctoPlus will receive an equity stake in Biolex of up to 3.0%.

    Separately, Biolex reported the close of a $60 million series D financing that will support ongoing Phase II testing of Locteron and prepare the compound for Phase III development.

    Under the original 2005 deal, Biolex and OctoPlus shared the commercial rights to Locteron. The revised agreement transfers full responsibility for development and commercialization to Biolex. OctoPlus will retain a royalty interest in the candidate and provide manufacturing and process development services.

    Locteron is a controlled-release interferon alfa designed to improve patient care in the treatment of hepatitis C through a more favorable side-effect profile and dosing convenience compared to existing pegylated interferon products, Biolex explains. It combines BLX-883, a recombinant interferon alfa produced by Biolex, with PolyActive®, an advanced controlled-release drug delivery technology developed by OctoPlus.

    Locteron is configured to allow dosing once-every-two-weeks, while currently marketed pegylated interferon alfa products require dosing every week, Biolex reports.

Be sure to take the GEN Poll

Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

More »