GEN Exclusives

More »

GEN News Highlights

More »
Oct 31, 2006

Avantogen’s IND for Pancreatic Cancer Drug Candidate Given Consent

  • Avantogen Oncology’s IND has been accepted for RP101, a compound that has shown to increase the median survival rate of patients with pancreatic cancer. "This important IND approval enables us to move RP101 to the next stage of clinical development and progress its assessment as a meaningful therapeutic for patients with pancreatic cancer," says Chris Nowers, CEO.

    Avantogen plans a Phase II, randomized, double-blind, placebo-controlled study assessing RP101 combined with gemcitabine chemotherapy versus gemcitabine chemotherapy alone in patients with metastatic pancreatic cancer. It will assess survival, with a primary efficacy endpoint at six months. Tumor response rate, progression-free survival, and safety will be evaluated as secondary endpoints. Patient accrual is currently targeted to begin early in 2007.

    Standard chemotherapy typically offers patients with advanced pancreatic cancer a median survival of approximately six months. Two open-label, multicenter, Phase I trials indicated that RP101 in combination with standard chemotherapy in patients with advanced pancreatic cancer increased median survival to approximately 14 months and nine months.


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

The Triple Package and Success

One theory for explaining “success," put forward by Amy Chua Jed Rubenfeld, posits cultural traits such as a superiority complex, personal insecurity and impulse control. Union College professors Joshua Hart and Christopher Chabris counter that intelligence, conscientiousness, and economic advantage are the most likely elements of success, regardless of ethnicity. Do you think that Hart-Chabris make a better argument for achieving success than the Chua-Rubenfeld theory?

More »