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Nov 7, 2006

Avalon Pharmaceuticals Commences Research on Elusive Survivin Pathway

  • Avalon Pharmaceuticals reported the start of a drug discovery program for the survivin pathway, an intractable cancer pathway. Survivin is overexpressed in multiple tumor types, including breast, lung, prostate, pancreatic, and colon. Additionally, survivin is cancer selective as it is undetectable in most normal adult cells.

    "The survivin pathway is recognized as a critical but elusive pathway for cancer therapeutics, because of its lack of enzymatic function," states David Bol, vp of pharmaceutical development at Avalon. "The survivin pathway intersects cellular networks critical for cancer cell function, including cell death, cell growth, and drug and radiation resistance."



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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

Do you agree that ecstasy should be studied for its potential therapeutic benefits?

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