GEN Exclusives

More »

GEN News Highlights

More »
Jun 2, 2010

Asuragen Obtains Rights to BRAF Mutation for Molecular Diagnostics

  • Asuragen obtained a nonexclusive license from Johns Hopkins University to incorporate the BRAF V600E mutation sequence into its molecular diagnostics. The BRAF V600E mutation may be used in diagnostic kits as well as the firm’s CLIA laboratory for clinical research and patient testing.

    Asuragen has integrated the BRAF mutation into its Luminex®-based Signature® KRAS mutation assays to expand coverage of the EGFR/MAPK signaling pathway. Asuragen will also offer BRAF mutation testing in its services laboratory for clinical trials and companion diagnostics studies.

    The V600E mutation in the BRAF oncogene results in a constitutively active BRAF protein. BRAF is a component of the EGFR/MAPK signaling pathway that is a target of several approved drugs as well as numerous drugs in clinical and preclinical development. The presence of this mutation has been shown to impact prognosis and the prediction of therapeutic response in colorectal cancer, Asuragen says. BRAF mutation also predicts a poorer prognosis in thyroid cancer. The mutation can be detected by testing DNA from tumor biopsies and resected tumor tissues.

    “This agreement with Johns Hopkins University will enable Asuragen to expand its mutation testing for a range of cancers,” notes Rollie Carlson, president of Asuragen. “The integration of BRAF into our existing multiplex tests on the Luminex platform allows us to provide rapid and streamlined tests for a number of clinical and research applications.”

Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

Patient Access to Genetic Information

Do you think patients have the absolute right to gain access to their own genetic information from medical or clinical laboratories?

More »