GEN Exclusives

More »

GEN News Highlights

More »
Nov 1, 2010

AOP Orphan Gives €1.25M Up Front in Deal for Shield’s Phase III-Stage Iron Therapy Product

  • Vienna-based AOP Orphan Pharmaceuticals is paying specialty pharmaceuticals firm Shield Holdings €1.25 million ($1.74 million) up front in return for rights to the latter’s Phase III-stage iron therapy product ST10-021 in Central Eastern Europe and the Middle East. As part of the deal AOP is also making an equity investment in a Shield subsidiary. Shield could in addition earn another €1.75 million ($2.4 million) in milestone payments.

    ST10-021 is an oral complex of ferric iron, which Shield is developing initially for the treatment of iron deficiency anemia (IDA) associated with inflammatory bowel disease. The firm says IDA affects some 73% of patients with ulcerative colitis or Crohn’s disease. The recently initiated Phase III program will include two parallel international trials. Shield also aims to develop ST10-021 for treating IDA associated with pre-dialysis chronic kidney disease. 

    Shield notes currently available oral treatments for IDA have limited effectiveness due to side effects and low levels of compliance, while intravenous therapies are expensive, inconvenient, and can cause hypersensitivity reactions. It claims that in contrast, ST10-021 is rapidly absorbed in the upper gastrointestinal tract, which may allow lower dosing and a reduction in the risk of gastrointestinal side effects. Activity of ST10-021 also appears to be independent to gastric pH, which may allow its prescription alongside drugs for reducing gastric acid.

    Founded in 2008, Shield is dedicated to commercializing late-stage, mineral-derived pharmaceuticals. Headquartered in Wollerau, Switzerland, the firm acquired its lead ST10-021 candidate earlier this year.


Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content

Jobs

GEN Jobs powered by HireLifeScience.com connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
 Searching...
More »

GEN Poll

More » Poll Results »

Tackling Climate Change

Do you think most companies will respond positively to the People’s Climate March?