Leading the Way in Life Science Technologies

GEN Exclusives

More »

GEN News Highlights

More »
Aug 4, 2010

Amplimmune Gets $23M Up Front from GSK to Develop PD-1-Targeting Drugs

  • Amplimmune will receive a $23 million up-front payment from GlaxoSmithKline (GSK) as part of a broad collaboration centered on developing PD-1-targeting therapeutics against cancer and other diseases. The agreement gives GSK exclusive, worldwide rights to AMP-224 and any new next-generation fusion proteins targeting PD-1. Amplimmune could receive up to $485 million in regulatory, development, and sales milestones plus sales royalties.

    GSK separately inked a deal with Five Prime focused on skeletal muscle disorders. The firm paid $15 million up front and additional fees of $124 million over and above research funding in 2011 and 2013.

    Amplimmune's AMP-224 is an Fc-fusion protein designed to block interaction between PD-1 and B7-H1 to overcome immune suppression and allow the immune system to fight cancer and chronic infections. Amplimmune says it expects to start Phase I trials with AMP-224 in cancer patients next year. The firm is also working to complete cGMP manufacturing and toxicology studies to support progression of AMP-224 into the clinic.

    The two partners will in addition work together to define the mechanism of action of AMP-224 and evaluate the fusion protein’s potential utility in oncology, infectious diseases, and vaccine applications. Excluding the Phase I trial with AMP-224, GSK will be responsible for all other development and manufacturing activities associated with product development.

    Amplimmune is focused on the development of immune-based biologics for treating cancer, autoimmunity, transplantation-related disorders, and infectious diseases. The firm’s platform, originally developed by its founders at Johns Hopkins University, centers on immunological checkpoint and co-stimulatory molecules as the basis for developing treatments that modulate critical mechanisms in the body's immune system. A mouse version of AMP-224 has already shown promising activity in mouse models of cancer and infectious disease, Amplimmune claims.

    In addition to AMP-224, the Amplimmune pipeline includes another preclinical-stage candidate, AMP-110, for the treatment of autoimmune diseases. AMP-110 targets T cells and is designed to elicit a co-inhibitory signal that suppresses T-cell responses.



Related content

Be sure to take the GEN Poll

CRISPR Patent Controversy

Do you think recently released email from a former Broad Institute scientist to Jennifer Doudna will expedite a final legal decision on who owns the CRISPR patent?

More »