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Dec 18, 2008

Adolor Shutters Phase III Development of OBD Drug

  • Adolor is nixing development of Entereg, its Phase III candidate for chronic opiate bowel dysfunction (OBD). In September, GlaxoSmithKline returned rights to Entereg covering various bowel dysfunction indications but retained rights to development in postoperative ileus (POI).

    Adolor reports that it based its decision on an assessment of the cost and timeline for an additional Phase III study relative to the remaining commercial life of Entereg in OBD.

    Instead, Adolor will focus on preclinical ADL7445, a peripherally acting mu-opioid receptor antagonist. The firm says that it is on track for for submission of an IND in mid-2009.

    Entereg received FDA approval earlier this year for the management of POI following bowel resection surgery.



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Scientifically Studying Ecstasy

MDMA (commonly known as the empathogen “ecstasy”) is classified as a Schedule 1 drug, which is reserved for compounds with no accepted medical use and a high abuse potential. Two researchers from Stanford, however, call for a rigorous scientific exploration of MDMA's effects to identify precisely how the drug works, the data from which could be used to develop therapeutic compounds.

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