GEN Exclusives

More »

GEN News Highlights

More »
Apr 27, 2009

Adjuvant IL-7 Boosts Vaccine-Induced Immune Response to Tumors

  • An international team of scientists found that after a vaccine-induced immune response, interleukin-7 (IL-7) improves antitumor activities and survival in an animal model of cancer.

    The findings are published in Nature Medicine in a paper called “Adjuvant IL-7 antagonizes multiple cellular and molecular inhibitory networks to enhance immunotherapies.”

    The scientists combined IL-7 with a viral vaccine and observed that together immunity to tumors was enhanced. They found that IL-6 production increased and T helper type 17 cell differentiation was augmented.

    Furthermore, IL-7 modulated the expression of two ubiquitin ligases: Casitas B-lineage lymphoma b (Cbl-b), a negative regulator of T-cell activation, was repressed, and SMAD-specific E3 ubiquitin protein ligase-2 (Smurf2) was enhanced, which antagonizes transforming growth-factor signaling.

    The scientists also explain that while short-term IL-7 therapy potently enhanced vaccine-mediated immunity, in the absence of vaccination it is inefficient in promoting antitumor immune responses, despite inducing homeostatic proliferation of T cells.

Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

The Triple Package and Success

One theory for explaining “success," put forward by Amy Chua Jed Rubenfeld, posits cultural traits such as a superiority complex, personal insecurity and impulse control. Union College professors Joshua Hart and Christopher Chabris counter that intelligence, conscientiousness, and economic advantage are the most likely elements of success, regardless of ethnicity. Do you think that Hart-Chabris make a better argument for achieving success than the Chua-Rubenfeld theory?

More »