GEN Exclusives

More »

GEN News Highlights

More »
Dec 3, 2007

Addex and Merck & Co. Take On Parkinson’s in $170.5M Alliance

  • Addex and Merck & Co. entered a $170.5 million deal focused on Parkinson’s disease. The exclusive research and licensing agreement includes rights to the Addex’ related preclinical program and the discovery and development of orally available drugs.

    Addex will receive $3 million upfront and is entitled to an additional $106.5 million in research, development, and regulatory milestones for the first product developed for multiple indications. Additionally, payments totaling $61 million will be made for a second and third developed product. Addex is also eligible to receive royalties on the sales of any products developed through this collaboration.

    Researchers will work to discover and develop positive allosteric modulators (PAMs) targeting the metatropic glutamate receptor 4 (mGluR4). The agreement also includes Addex’ lead mGluR4 PAMs, that have reportedly reduced symptoms and slowed the progression of the disease. The program is reportedly in the lead optimization phase.

    Although both companies will jointly work on preclinical development, Merck will be responsible for clinical development. Addex will participate in the joint oversight committee and retains the option of copromoting in certain EU countries.


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

The Triple Package and Success

One theory for explaining “success," put forward by Amy Chua Jed Rubenfeld, posits cultural traits such as a superiority complex, personal insecurity and impulse control. Union College professors Joshua Hart and Christopher Chabris counter that intelligence, conscientiousness, and economic advantage are the most likely elements of success, regardless of ethnicity. Do you think that Hart-Chabris make a better argument for achieving success than the Chua-Rubenfeld theory?

More »