GEN Exclusives

More »

GEN News Highlights

More »
Dec 19, 2012

100K Genome Project, OpGen Tackle Foodborne Illnesses

  • OpGen is teaming up with the University of California, Davis, (UC Davis) in cooperation with the FDA-supported 100K Genome Project to create high-resolution microbial genetic maps.

    The 100K Genome Project is a collaboration that was initiated earlier this year by the U.S. Food and Drug Administration (FDA), UC Davis, and Agilent Technologies to sequence the genetic code of at least 100,000 infectious organisms including Salmonella, Listeria, and E. coli, and accelerate the diagnosis of foodborne illnesses. UC Davis will integrate OpGen’s Argus Whole Genome Mapping System into its current DNA sequencing workflow for sequence assembly and validation of the genomes.

    Through the integration of OpGen’s Whole Genome Mapping technology, The 100K Genome Project aims to create a new standard for microbial reference genomes. These data will reportedly be used in the surveillance and management of international foodborne microbial outbreaks, and to establish a high-fidelity global reference database for microbial genomes. The 100K Genome Project will publish the genomes that are completed and validated using OpGen’s Whole Genome Maps to a database, providing access to the genomic maps for public health agencies throughout the world. The FDA is advocating rigorous quality control standards for this reference database whereby genomic information should be validated by two independent methods.

    “OpGen’s technology allows us to complete sequencing and provide quality control of genomes drafted by data produced using short-read next-generation sequencing methods,” said Bart C. Weimer, Ph.D., who is a professor in the department of population and reproduction at UC Davis' School of Veterinary Medicine, and the director of the 100K Pathogen Genome Project. “Whole Genome Mapping provides an independent method to detect sequence variations and misassemblies, and aids us in closing the gaps.”

    The Argus Whole Genome Mapping System has been gaining popularity lately, as, according to OpGen, the Genome Institute at Washington University, St. Louis, MO; the Genome Analysis Centre (TGAC) in Norwich, UK; Genoscope in Evry, France; the National High-throughput DNA Sequencing Center at the Center for GeoGenetics, Copenhagen, Denmark; and the Genome Institute of Singapore have all recently adopted the technology.

Add a comment

  • You must be signed in to perform this action.
    Click here to Login or Register for free.
    You will be taken back to your selected item after Login/Registration.

Related content


GEN Jobs powered by connects you directly to employers in pharma, biotech, and the life sciences. View 40 to 50 fresh job postings daily or search for employment opportunities including those in R&D, clinical research, QA/QC, biomanufacturing, and regulatory affairs.
More »

Be sure to take the GEN Poll

Patient Access to Genetic Information

Do you think patients have the absolute right to gain access to their own genetic information from medical or clinical laboratories?

More »