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July 31, 2014

Golgi—A Potential Drug Target for Alzheimer's Disease

In this literature review, the authors show how accumulation of amyloid beta peptides leads to Golgi fragmentation.

Golgi—A Potential Drug Target for Alzheimer's Disease

Golgi fragmentation in AD is caused by phosphorylation of Golgi structural proteins, which is induced by A&#946-triggered cyclin-dependent kinase-5 activation. [© psdesign1 - Fotolia.com]

First described in 1906 by Alois Alzheimer, Alzheimer's disease (AD) represents the most common form of dementia today and the sixth leading cause of death in the United States (Alzheimer's Association) Symptomatically, this fatal neurodegenerative disorder is most often characterized by loss of memory and decreased abilities in orientation and ...

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