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December 01, 2008 (Vol. 28, No. 21)

Zeroing in on PI3K Pathway

Myriad of Groups Are Working on the Latest Hot Target and Most Are Optimistic About Its Potential

  • Although the term “signal transduction” was coined back in 1972, cell-signaling switches have only recently become one of the hottest targets in cancer research. The latest star is the phosphoinositide 3-kinase (PI3-kinase) pathway—playing key roles in angiogenesis, cell growth, differentiation, and survival, as well as glucose metabolism. It is ...

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