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June 15, 2014 (Vol. 34, No. 12)

Therapeutic siRNA Interventions

From our June 15 issue: Treatments based on RNA interference are improving now that technologies are delivering longer-lasting gene silencing.

  • The 2006 Nobel Prize in Physiology or Medicine was awarded jointly to Andrew Z. Fire and Craig C. Mello for their 1998 discovery of RNA interference (RNAi), gene silencing by double-stranded RNA. Today, RNAi-based therapeutics are in Phase II and Phase III clinical trials. The rapid development of ...

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