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March 01, 2009 (Vol. 29, No. 5)

TechNote: High-Throughput Kinase Selectivity Profiling

Bridging the Gulf between Compound Libraries and Rapid Discovery

  • Protein kinase-focused drug discovery efforts are escalating rapidly as research continues to elucidate and define the role of kinases in a growing list of diseases. To date, these research efforts have yielded eight FDA-approved small molecule kinase inhibitors with over 500 more in active development. While kinase inhibitors demonstrate ...

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