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TechNote: Ca2+ Signal Detection in HTS Operations
Improved Reporting for Agonists and Antagonists of GPCRs and Ion Channels
- The bivalent ion Ca2+ is a critical second messenger involved in many physiological and signal transduction processes within a cell. The central role of Ca2+ in intracellular signalling, and its physical/chemical properties also makes it an attractive reporting molecule for drug discovery. GPCRs, ion channels, and ion exchangers are ...
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