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August 01, 2006 (Vol. 26, No. 14)

TechNote: Ca2+ Signal Detection in HTS Operations

Improved Reporting for Agonists and Antagonists of GPCRs and Ion Channels

  • The bivalent ion Ca2+ is a critical second messenger involved in many physiological and signal transduction processes within a cell. The central role of Ca2+ in intracellular signalling, and its physical/chemical properties also makes it an attractive reporting molecule for drug discovery. GPCRs, ion channels, and ion exchangers are ...

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