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August 01, 2006 (Vol. 26, No. 14)

TechNote: Antibiotic-Free Systems for Production

Bypassing the Expression of Exogenous Site-Specific Recombinases

  • The use of antibiotic resistance markers to select for a successful genetic modification, such as a chromosomal insertion or a plasmid transformation, is common practice. However, with increasing stringency in manufacturing regulations it is essential to ensure that the end product contains no antibiotics and no genes for antibiotic ...

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