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March 01, 2014 (Vol. 34, No. 5)

TAL Effectors for Genome Editing

TALEs Enable Rapid and Easy Design of Effectors to Control Gene Expression in Cells

  • The ability to target a functional protein to a user-defined DNA sequence is a long-sought goal with the potential to enable genome engineering and genetic regulation of diverse cell types. Transcription activator–like effectors (TALE) proteins derived from the bacterial pathogen Xanthomonas have emerged as versatile scaffolds for engineering DNA-binding ...

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