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January 01, 2013 (Vol. 33, No. 1)

Tackling Transfection Tasks

  • The discovery in the early 1990s that administration in mice of plasmid DNA encoding both viral and nonviral antigens induced antibody responses held out the prospect of achieving broad immunogenicity using DNA vaccines without the safety issues associated with a replicating pathogen. Despite this promise, the efficacy of ...

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