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Sep 1, 2010 (Vol. 30, No. 15)

Spotlight on New Mass Spec Systems

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    AB Sciex reports that its TripleTOF™ 5600 System provides accurate mass at the speed and sensitivity of a triple quadrupole.

    A number of novel tools and technologies were showcased at the ASMS meeting. The highlighted instruments and software improve precision, speed, accuracy, and sensitivity.

    > AB Sciex  introduced the TripleTOF™ 5600 System, with features such as SmartSpeed™ with 100 Hz acquisition capability and 10 millisecond acquisition times; the Accelerator TOF Analyzer, in which the ion beam is pulsed into the TOF at 30 kHz, reflected to the bottom of the tube and then back to the top where the detector sits; and EasyMass™ Accuracy to ensure stable mass accuracy of about
    1 ppm without continuous user calibration.

    The 5600 system offers the quantitative capabilities of a triple quadrupole instrument using TOF technology, according to the company. The system can achieve more than 30,000 FWHM resolution across a range of speeds and offers a linear dynamic range of about four orders of magnitude.

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    According to Agilent Technologies, its iFunnel technology drives sensitivity gains in atmospheric pressure ion sampling for most applications. Agilent Jet Stream technology creates accessible gas-phase ions, which are drawn into the mass spec through a hexabore capillary sampling array. The ions are focused and separated from the gas by a dual-ion funnel assembly.

    > Agilent Technologies highlighted its new 6490 Triple Quadrupole LC/MS System with iFunnel technology, which utilizes the company’s  Jet Stream thermal gradient focusing technology to maximize the accessible gas-phase ions, which then enter the spectrometer through a six-capillary sampling array.

    According to Agilent, the 6490 can detect molecules at the 10–21, or zeptomole, level. Agilent recently completed its acquisition of Varian, resulting in the addition of ion trap and FTMS technology to its MS portfolio.

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    Bruker’s autoflex speed series incorporates the firm’s smartbeam-II laser technology, which combines the advantages of nitrogen lasers with the reliability of all-solid-state lasers.

    > In May, Bruker completed its acquisition of three product lines from Varian, which become part of the company’s new Bruker Chemical Analysis Division, a business unit of Bruker Daltonics.

    Included in this deal, in which Agilent divested certain product lines as part of its deal to acquire Varian, are Varian’s gas chromatography (GC) instrument, GC triple-quadrupole MS system, and the inductively coupled plasma MS system.

    At ASMS, Bruker launched a new product in its FLEX™ MALDI-TOF MS series, called the autoflex speed. It utilizes a 1 KHz smartbeam™-II laser, the company’s FlashDetector™ system, and a 4 GS/s digitizer. It offers a broad mass range, >26,000 FWHM resolving power at high throughput, and panoramic (PAN™) technology.

    The MALDI Perpetual™ self-cleaning ion source reportedly cleans itself within 15 minutes without breaking the vacuum. Bruker also launched a MALDI source for the solariX™ FTMS. Its dual-ion funnel design allows for switching between MALDI and ESI ion sources.

    Based on work with collaborating scientists, Bruker presented studies demonstrating the use of its maxis ETD QqTOF instrument to perform Edmass™ top-down sequencing of intact proteins of >60 kD molecular weight.



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