In the United States, more than a dozen needle-free jet injectors have been licensed by the FDA and are on the market. One of the more popular needle-free jet injectors is the Biojector 2000. This device is being used by over 120 office-based physicians in the U.S., according to Bioject. Currently, each manufacturer makes its own type of cartridge that holds the vaccine and is attached to the device before injection. None of these cartridges is interchangeable, which is a major limitation to their widespread use.
Vitajet, also from Bioject, is a nozzle-type delivery system, currently used to deliver subcutaneous injections of insulin. The device has three components: the reusable injection device, disposable nozzle, and disposable vial holder. The nozzle is replaced once a week. It may be used in the home for self-administration. The Vitajet 3 is powered by an internal spring, and more than 3,000 injections may be delivered from a single device.
Merck Serono’s SeroJet is a needle-free injection system for delivering Serostim recombinant human growth hormone for treatment of HIV-associated wasting in adults. PowderMed, which was acquired by Pfizer, delivers DNA-coated microscopic gold particles into the skin using pressurized helium gas. The particles penetrate the skin, activating cells that, in turn, trigger an immune response.
The Intraject system by Zogenix, a prefilled, disposable, needle-free injector, is suitable for a wide range of liquid drugs, including pharmaceuticals, therapeutic proteins, and vaccines, according to the company.
Glide Pharma’s Glide SDI, which is intended for the injection of solid doses, is composed of a pen-like actuator and cassette containing the medicine in the form of a tiny, rod-shaped solid dosage form.
Antares Pharma’s Medi-Jector Vision is a small, handheld device that uses pressure to create a microthin stream of insulin that penetrates the skin and is deposited into the subcutaneous tissue in a fraction of a second. This seventh-generation device reportedly offers the comfort of needle-free injection without compromising on convenience or ease of use. In June, the FDA approved the Tev-Tropin Tjet injector system, on which Teva and Antares collaborated.
Crossject from Crossject Medical Technology is a single-use prefilled needle-free injection targeted for subcutaneous, intramuscular, or intradermal use. There is no pressurized gas present while the injector is kept in storage, thus avoiding the difficulties of gas leakage.