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November 01, 2013 (Vol. 33, No. 19)

RNAi Screens and the Reagents That Enable Them

  • RNAi screens for functional genomics typically look for loss- or gain-of-function phenotypes. They currently have many applications, including target discovery and validation, lead identification and optimization, mechanism of action discovery, predictive toxicology, and biomarker identification. While reagents are gaining ground, technical difficulties remain in how best to perform ...

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