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Apr 1, 2008 (Vol. 28, No. 7)

Revolutionizing Protein Expression in R&D Arena

Designing Better Systems to Energize Therapeutic Pipelines

  • “One of the case studies we showed in the presentation is to enhance the expression and secretion of the mature macrophage inhibitory cytokine-1. We have identified one of the rate-limiting steps for the folding of the protein based on a novel glycosylation mechanism and are able to significantly increase the secretion of the mature dimeric form of the protein. This mutation and expression process can be easily adapted into 510K GMP production for our diagnostic products.”

    Diagnostic kits for colon cancer, ovarian cancer, and breast cancer are currently in the works, added Dr. Wolfert. In creating immunoassay systems he emphasizes that he wants proteins that are native in structure yet amplified in nature. “We want to actually reflect proteins that are released in the blood stream.”



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