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March 01, 2010 (Vol. 30, No. 5)

PTMs Progress Toward Designer Proteins

Advances in the Analysis and Biosynthesis of Glycans Are Transforming the Field

  • Of the essential post-translational modifications (PTMs) that proteins undergo before their synthesis is complete, glycosylation is arguably the best known. The medical and economic significance of monoclonal antibodies and other glycoproteins has spurred a resurgence of interest in glycans, particularly in their analysis and ways to direct their biosynthesis ...

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