Patient noncompliance to treatment leads to adverse health effects and increased costs. When personalized therapies prove more effective or present fewer side effects, patients will be more likely to comply with their treatments. The greatest impact could be for the treatment of diseases such as asthma and diabetes, in which noncompliance commonly exacerbates the condition. At least one study supports this point.
Inherited forms of hypercholesterolemia (high cholesterol) can increase the risk of myocardial infarction before the age of 40, more than 50-fold in men and 125-fold in women. Conventional monitoring of cholesterol levels can catch the condition early, but genetic testing offers additional benefits.
In addition to detecting the condition before there are observable signs of disease, knowledge of a genetic predisposition for hypercholesterolemia provides patients with a powerful incentive to make lifestyle changes and to treat their condition seriously. Patients with a genetic diagnosis have shown more than 86% adherence to their treatment program after two years compared to 38% prior to testing.